ML130 (Nodinitib-1)
ML130 (Nodinitib-1)
CAS: 799264-47-4
Molecular Formula: C14H13N3O2S
ML130 (Nodinitib-1) - Names and Identifiers
ML130 (Nodinitib-1) - Physico-chemical Properties
| Molecular Formula | C14H13N3O2S |
| Molar Mass | 287.34 |
| Density | 1.40±0.1 g/cm3(Predicted) |
| Melting Point | 191-192 °C (decomp) |
| Boling Point | 532.5±43.0 °C(Predicted) |
| Solubility | DMSO: >10mg/mL |
| Appearance | powder |
| Color | white to beige |
| pKa | 2.55±0.10(Predicted) |
| Storage Condition | Keep in dark place,Sealed in dry,2-8°C |
| MDL | MFCD04322367 |
| Use | Nodinitib-1 |
| In vitro study | ML130 can selectively inhibit nod1-induced NF-κB activation in HEK293 cells without cytotoxicity and has been selected as a potential probe molecule. In the second experiment, ML130 was also shown to selectively inhibit nod1-dependent IL-8 secretion and nod1-dependent NF-κB activation pathway. Another study found that ML130 can cause conformational changes of NOD1 in vitro and its intracellular subcellular localization, this provides a chemical probe for studying the regulation mechanism of NOD1 activity and also provides a tool for studying the role of NOD1 in various infectious and inflammatory diseases. |
ML130 (Nodinitib-1) - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | 22 - Harmful if swallowed |
| WGK Germany | 3 |
ML130 (Nodinitib-1) - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.48 ml | 17.401 ml | 34.802 ml |
| 5 mM | 0.696 ml | 3.48 ml | 6.96 ml |
| 10 mM | 0.348 ml | 1.74 ml | 3.48 ml |
| 5 mM | 0.07 ml | 0.348 ml | 0.696 ml |
Last Update：2024-01-02 23:10:35
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